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Icatibant Acetate
🥰Excellent
Catalog No. T22344Cas No. 138614-30-9
Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.
Icatibant Acetate
🥰Excellent
Purity: 98%
Catalog No. T22344Cas No. 138614-30-9
Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 60 € | In Stock | |
| 2 mg | 93 € | In Stock | |
| 5 mg | 187 € | In Stock | |
| 10 mg | 297 € | In Stock | |
| 25 mg | 501 € | In Stock | |
| 50 mg | 715 € | In Stock | |
| 100 mg | 937 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 375 € | In Stock |
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Purity:98%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema. |
| Targets&IC50 | Bradykinin B2:0.798 nM(ki), Bradykinin B2:1.07 nM |
| In vitro | Icatibant is a decapeptide resistant to the bradykinin-degrading proteases, leading to a longer half-life than bradykinin which it antagonizes[1]. |
| In vivo | Icatibant treatment exhibits efficacy in bradykinin-mediated angioedema attacks, and rapidly relieves symptom [1]. |
| Molecular Weight | 1364.57 |
| Formula | C61H93N19O15S |
| Cas No. | 138614-30-9 |
| Smiles | CC(O)=O.[H][C@]12C[C@H](N(C(=O)[C@H]3Cc4ccccc4CN3C(=O)[C@H](CO)NC(=O)[C@H](Cc3cccs3)NC(=O)CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](N)CCCNC(N)=N)[C@@]1([H])CCCC2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
| Relative Density. | 1.6g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (73.28 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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